CAR T Initiative

About CAR T

A New Frontier

Cancer therapies have improved dramatically over the last several years, due to the development and discovery of novel therapies resulting from the science and research conducted at AACI cancer centers. Among these are chimeric antigen receptor T-cell (CAR T) therapies. CAR T therapies represent a critical advancement in treating malignancies, and evidence shows these therapies provide important clinical benefits to patients.

In 2017, the Food and Drug Administration (FDA) approved tisagenlecleucel (Kymriah®) and axicabtagene ciloleucel (YESCARTA®) CAR T-cell therapies for the treatment of certain relapsed or refractory leukemias and lymphomas. More than half of AACI’s member centers have been approved to provide these therapies. However, with these novel treatments come new challenges. To address  barriers associated with administering the therapies, AACI formed the CAR T Initiative.

The initiative facilitates collaboration between subject matter experts at AACI’s member centers through webinars, listserv discussions, calls, meetings, and other activities. The steering committee has also submitted comments to the Centers for Medicare & Medicaid Services (CMS) on their proposed national coverage analysis.

Steering Committee

The CAR T Initiative Steering Committee helps guide and implement CAR T-cell therapy programs at AACI member centers across North America.

Chair
Joseph McGuirk, DO
The University of Kansas Cancer Center

View All Steering Committee Members

Working Groups

As part of the CAR T Initiative, topic-specific working groups have been formed to facilitate discussion on the challenges of administering these therapies as well as to develop and disseminate best practices and solutions.

Co-chairs

Richard Bondi  |  UPMC Hillman Cancer Center
Clint Divine, MBA, MSM  |  The University of Kansas Cancer Center

Co-chairs

David Porter, MD  |  Abramson Cancer Center of the University of Pennsylvania
Miguel-Angel Perales, MD  |  Memorial Sloan Kettering Cancer Center

Chair

Frederick L. Locke, MD  |  Moffitt Cancer Center