The Clurman lab (https://research.fredhutch.org/clurman/en.html works at the intersection of two fields: cell cycle control and protein degradation by the ubiquitin-proteasome system. Our work focuses on both tumorigenesis and normal biology, and our overall goal is to apply new mechanistic insights to understand cancer development and to develop new therapeutic strategies.
The Fred Hutch/University of Washington Head and Neck Research Program- Fred Hutch and the University of Washington have a world-class program in Head and Neck Cancer that spans from clinical to translational to basic research. The program drives collaborative research among its members, and its unique assets include a surgical core that provide fresh tumor specimens and PDX models, novel engineered murine models, state of the art-AI-enabled drug screening in microtumors and cancer cells, and more.
Responsibilities
The Clurman lab is seeking a highly qualified and motivated Post-Doctoral Research Fellow. The project will study molecular pathogenesis and therapeutic strategies associated with two promising cell cycle targets in head and neck squamous cell cancer (HNSCC), Wee1 and CDK4/6. Primarily based in the Clurman lab, this position also provides the opportunity to work collaboratively with other Fred Hutch research groups within the HNSCC team, including Taran Gujral (machine learning-enabled drug screening), Slobodan Beronja (mouse models of HNSCC), and Patrick Paddison (functional genomics). This work will encompass a broad array of cell and molecular biology approaches, including high-throughput functional genomics and drug screening, gene expression and analyses in tissue culture cells, murine models of cancer, and genomics/proteomics. We value lab members who are highly collaborative but can also independently develop and guide research projects.
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Qualifications
MINIMUM QUALIFICATIONS:
PhD, M.D., or M.D., Ph. D (or equivalent degree) in cell and molecular biology, cancer biology, biochemistry, or a related field
Broad expertise in cell and molecular biology methods and the ability to master new techniques and approaches
Experience with mouse models and xenografting is preferred
Experience in functional genomics and/or drug screening also preferred
Excellent written and oral communication skills
Record of productive and rigorous research, including at least one primary publication in an impactful peer-reviewed journal
Ability to independently plan, conduct, and analyze research.
The annual base salary range for this position is from $77,976 to $95,014, and pay offered will be based on experience and qualifications.
This position is not eligible for H1-B sponsorship at this time.
Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).