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News from the Association of American Cancer InstitutesApril 2016
The Association is dedicated to reducing the burden of cancer by enhancing the impact of the nation's leading academic cancer centers.
AACI Update is an e-newsletter for the cancer center directors and key contacts at AACI member institutions and individuals interested in the cancer center-related activities of AACI. AACI Update reports on the progress of AACI initiatives and other AACI endeavors that benefit the cancer community and highlights important news and events at AACI member institutions.

AACI encourages member institutions to submit cancer center highlights to AACI Update. News briefs are linked to complete stories posted on individual cancer center websites. Please e-mail materials to aaciupdate@aaci-cancer.org. AACI reserves the right to decide whether or not materials are appropriate for inclusion.

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Headlines

CRI Annual Meeting Registration Now Open

Registration is now available online for the 8th Annual AACI Clinical Research Initiative Meeting. The meeting will be held July 20-21, in Chicago, IL, at the Loews Chicago O'Hare Hotel.

Register now! Registration rates will increase on April 30. Please also note that the deadline for submitting abstracts for consideration for presentation at the meeting is Monday, May 9, at 5:00 PM PST. more...

ASCO, AACI Hold Workshop on Best Practices in Cancer Clinical Trials
On March 8, the American Society of Clinical Oncology (ASCO) and the Association of American Cancer Institutes (AACI) held the Best Practices in Cancer Clinical Trials Workshop at ASCO Headquarters in Alexandria, VA. More than 60 attendees participated in the event, which focused on developing solutions that could improve the efficiency of conducting clinical trials today. more...

Government Relations Forum Convenes at Duke Cancer Institute
On Friday, March 18, more than 20 cancer center government relations representatives gathered at Duke Cancer Institute for the annual spring meeting of the AACI Government Relations Forum. Participants discussed federal and state policy issues affecting cancer centers. more...

Register Now for Hill Day on May 12
Register today to attend AACI's annual Hill Day on Thursday, May 12, 2016, in Washington, DC. Advocates will visit Capitol Hill to thank Members of Congress for their renewed commitment to the National Institutes of Health (NIH) and the National Cancer Institute (NCI) in Fiscal Year 2016 and to request a robust investment for these agencies in Fiscal Year 2017 and beyond. more...

AACI and AACR Support Proposed Rule to Regulate Indoor Tanning
In March, AACI joined the American Association for Cancer Research (AACR) in submitting comments supporting the U.S. Food and Drug Administration (FDA)'s recently released proposed rule to prevent persons under the age of 18 from using indoor tanning facilities, and to require indoor tanning facility customers over the age of 18 to initially sign paperwork acknowledging the risks of indoor tanning and to sign paperwork every six months thereafter. more...

Moffitt Hosts Cancer Policy Forum
On March 7, Moffitt Cancer Center hosted a Cancer Research Policy Forum: Progress, Promise, and Challenges in the Era of Precision Medicine with the American Association for Cancer Research (AACR) and with the support of AACI. The full recording of the forum is now available. more...

Vice President Continues Moonshot Listening Tour at Cancer Centers
Vice President Joe Biden continues his National Cancer Moonshot Initiative, by visiting cancer centers across the country. The Vice President's initiative aims to break down barriers and encourage collaboration among academia, the government and the private sector in order to deliver more effective treatments and therapies to patients. The Vice President is learning of breakthroughs taking place at our nation's cancer centers, discovering the advances possible through immunotherapies, genomics, and combination therapies. A timeline of the Vice President's initiative is below. To update AACI on an upcoming visit with the Vice President, please contact mail@aaci-cancer.org more...

Online Registration Opens April 13 for AACI/CCAF Annual Meeting
The 2016 AACI/CCAF Annual Meeting will be held in Chicago from October 23-25. Information on the meeting, including the program and electronic registration, will be available on the AACI website on Wednesday, April 13. more...
News from the Centers
Awards & Honors
Martell Foundation Lauds Pietenpol Research
Vanderbilt-Ingram Cancer Center
Jennifer Pietenpol, PhD, director of Vanderbilt-Ingram Cancer Center, was honored with the Medical Research Advancement Award during the 8th Annual T.J. Martell Foundation Nashville Honors Gala. The Medical Research Advancement Award is in recognition of Dr. Pietenpol's career as a cancer researcher. She focuses on the p53 family of proteins and breast cancer, especially triple-negative breast cancer, which is one of the most difficult to treat forms of the disease. more...
Karmanos Recognized for Contributions to Multiple Myeloma Research
Barbara Ann Karmanos Cancer Institute
Karmanos Cancer Institute has received the Accelerator Award from the Multiple Myeloma Research Foundation (MMRF) for its contributions to multiple myeloma research and particularly patient enrollment to clinical trials. The MMRF announced the recipients of the Accelerator Award, as well as the Innovator Award and the Collaborator Award at the recent 57th ASH (American Society of Hematology) Annual Meeting in Orlando, Fla. Previous winners of the Accelerator Award include some of the top myeloma programs in the country such as Dana Farber Cancer Institute and Emory University. Jeffrey Zonder, MD, leads the Multiple Myeloma and Amyloidosis team at Karmanos. more...
Hematologists Named ASH Scholar Award Recipients
Siteman Cancer Center
Three blood cancer researchers at Washington University School of Medicine in St. Louis will receive the 2016 American Society of Hematology (ASH) Scholar Award. Stephen Oh, MD, PhD, and Christopher Sturgeon, PhD, also are Siteman Cancer Research members. Hamza Celik, PhD, a postdoctoral research fellow, was recognized in the Basic Research Fellows category. He will receive a two-year, $100,000 grant. The ASH Scholar Award program supports fellows and junior faculty dedicated to careers in hematology research as they transition from training programs to careers as independent investigators. more...
Chicago Researchers Receive ASCO Awards for Contributions to Cancer Care
The University of Chicago Medicine Comprehensive Cancer Center
Philip Hoffman, MD, and Susan Cohn, MD, will be honored with the American Society of Clinical Oncology's highest honor, its Special Awards, during the 2016 American Society for Clinical Oncology (ASCO) Annual Meeting in June. Dr. Hoffman will receive the Excellence in Teaching Award and Dr. Cohn will receive the Pediatric Oncology Award. In addition, Dr. Cohn and Gini F. Fleming, MD, will be named ASCO Fellows. more...
Greenberg Receives American Urologic Association Award
Fox Chase Cancer Center, Temple Health
Richard E. Greenberg, MD, FACS, chief of urologic oncology at Fox Chase Cancer Center, will receive the 2016 American Urologic Association (AUA)'s Residents Committee Teaching Award at the organization's annual meeting in San Diego this May. The award is presented annually to an outstanding urology educator or program director who has dedicated a portion of his/her career to teaching residents. This award also recognizes an individual who influences residents to pursue a career in academic medicine. more...
Mardis Honored by American Association for Clinical Chemistry
Siteman Cancer Center
Elaine Mardis, PhD, co-director of The McDonnell Genome Institute at Washington University School of Medicine in St. Louis and a Siteman Cancer Center research member, has been recognized by the American Association for Clinical Chemistry for exceptional research and service in the field of laboratory medicine. more...
Era of Hope Scholar Award Goes to Zhang
The Dan L. Duncan Comprehensive Cancer Center
Xiang Zhang, PhD, a McNair Scholar and Assistant Professor in the Lester and Sue Smith Breast Center at Baylor College of Medicine, has been awarded the Department of Defense's 2015 Breast Cancer Research Program Era of Hope Scholar Award to further study metastatic breast cancer. more...
Foti Honored with Society of Surgical Oncology Award
American Association for Cancer Research
Margaret Foti, PhD, MD (hc), chief executive officer of the American Association for Cancer Research, was recognized during the plenary session at the 69th Society of Surgical Oncology Annual Cancer Symposium in Boston, with the James Ewing Layperson's Award for her dedication to the prevention and cure of cancer and her unstinting commitment to increasing public awareness about cancer and the importance of cancer research for improving public health. more...
Grants & Gifts
Hopkins Launches Research Center with $125 Million from Bloomberg, Kimmel, Others
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins will launch an institute devoted to the study of a new and promising approach to cancer treatment, embracing the Obama administration's "moonshot" initiative to cure cancer, an effort led by Vice President Joe Biden. The Bloomberg–Kimmel Institute for Cancer Immunotherapy was founded with two $50 million gifts-one from Michael R. Bloomberg, philanthropist, entrepreneur, and three-term mayor of New York City; the other from philanthropist Sidney Kimmel, founder of Jones Apparel Group. An additional $25 million for the center was contributed by more than a dozen additional supporters. more...
Team Receives $7.38 Million Grant from California's Stem Cell Agency
City of Hope Comprehensive Cancer Center
A research team led by Yanhong Shi, PhD, director of the Division of Stem Cell Biology Research, has received a $7.38 million grant from the California Institute for Regenerative Medicine to develop a novel treatment for Canavan disease, a rare and fatal neurological disease that afflicts infants. more...
Kirsch Receives Outstanding Investigator Award
Duke Cancer Institute
The National Cancer Institute has awarded a prestigious Outstanding Investigator Award to David G. Kirsch, MD, PhD, professor in the departments of Radiation Oncology and Pharmacology and Cancer Biology at Duke Health. The $6.6 million award, covering seven years, will fund ongoing research in Dr. Kirsch's lab to improve the efficacy and safety of radiation therapy for people with cancer. more...
NCI Outstanding Investigator Gets $6.4M for Discovering Cancer Viruses
University of Pittsburgh Cancer Institute
Patrick Moore, MD, MPH, has received the National Cancer Institute (NCI) Outstanding Investigator Award, a top honor given to accomplished cancer researchers, and was awarded $6.4 million to further his work into the link between viruses and cancer. This NCI grant recognizes exceptional past achievements to provide seven years of secured support, giving the investigator freedom from the pressure of ongoing grant competitions. Dr. Moore's award makes him the second researcher at the University of Pittsburgh Cancer Institute to receive this recognition, given to just 60 people in the country since the grant program was created in 2014. more...
Sebti Receives NCI Outstanding Investigator Award
Moffitt Cancer Center
Said M. Sebti, PhD, chair of the Drug Discovery Department and co-leader of the Chemical Biology and Molecular Medicine Program at Moffitt Cancer Center, has been awarded an Outstanding Investigator Award from the National Cancer Institute (NCI). The prestigious award, which provides grant funding over a seven year term, is given to well-established cancer researchers with proven track records to encourage long-term projects of unusual potential in cancer research. Dr. Sebti's award totals $6,415,284 million. more...
City of Hope, Israel Cancer Research Fund Create Program for Cancer Research
City of Hope Comprehensive Cancer Center
City of Hope and the Israel Cancer Research Fund (ICRF) have established the Jacki and Bruce Barron Cancer Research Scholars' Program, made possible with a $5 million gift from The Harvey L. Miller Family Foundation. The new program will promote innovative and collaborative research, as well as the exchange of ideas and information between exceptional cancer researchers in the United States and Israel. more...
Brain Cancer Researcher Receives Hyundai Grant
UF Health Cancer Center
University of Florida Health's Duane Mitchell, MD, PhD, has received a $1 million grant from the nonprofit Hyundai Hope On Wheels to further his research into stimulating immune responses against malignant brain tumor cells. Dr. Mitchell received one of four new Quantum Grants, given to institutions committed to transformational research on pediatric cancers with the lowest survival rates. more...
Leadership Transitions
Hudis Named ASCO CEO
American Society of Clinical Oncology
Clifford A. Hudis, MD, FACP, Chief of the Breast Medicine Service at Memorial Sloan Kettering Cancer Center, where he also serves as Vice President for Government Relations and Chief Advocacy Officer, and a Professor of Medicine at Weill Cornell Medical College, has been named the next Chief Executive Officer of the American Society of Clinical Oncology (ASCO). He will succeed Allen S. Lichter, MD, FASCO, who is stepping down after ten years of service in the CEO position. Dr. Hudis is among the world's most recognized experts in breast cancer treatment and prevention, and is a former President (2013-2014) and Board member of ASCO. He will begin his new position on June 27, 2016. more...
Pratt-Chapman to Serve as Associate Center Director for Patient Centered Initiatives and Health Equity
George Washington Cancer Institute
The GW Cancer Center has announced that Mandi Pratt-Chapman has been tapped to serve as the Associate Center Director for Patient Centered Initiatives and Health Equity. In this role, Pratt-Chapman will serve on the senior leadership team for the newly-formed GW Cancer Center, leading national research on patient-centered care and integrating research into practice. more...
New Executive Director at NYU Langone
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Timothy W. Strawderman, PhD, has been named the new Executive Director of the Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, an NCI-designated cancer center. Dr. Strawderman will take his new position effective May 2016. more...
Leading Surgeon and Scientist Appointed Director of Gynecologic Oncology
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Surgeon and scientist Douglas A. Levine, MD, FACOG, FACS, whose seminal biomarker research has helped to advance early detection and treatment of ovarian cancer, will join the faculty of NYU Langone Medical Center as director of the Division of Gynecologic Oncology at its Laura and Isaac Perlmutter Cancer Center and the Department of Obstetrics and Gynecology, effective May 15, 2016. more...
Weiner Appointed Executive Vice President and Director of Vaccine Center
The Wistar Institute
The Wistar Institute, an international biomedical research leader in cancer, immunology and infectious diseases, announces the appointment of preeminent immunologist and vaccine expert David B. Weiner, PhD, as executive vice president of The Wistar Institute, director of the Vaccine Center, and the W. W. Smith Endowed Chair in Cancer Research. more...
GI Medical Oncology Chief Elected NCI Task Force Vice Chair
Fox Chase Cancer Center, Temple Health
Steven J. Cohen, MD, chief of gastrointestinal medical oncology at Fox Chase Cancer Center, has been elected by his peers to serve as Vice Chair of the NCI Pancreas Task Force of the Gastrointestinal Steering Committee. In his new role, Dr. Cohen will regularly lead and participate in the discussion of clinical trial ideas under development and other decision-making activities of the Task Force. more...
Maha Hussain to Join the Lurie Cancer Center
The Robert H. Lurie Comprehensive Cancer Center
Internationally renowned clinical researcher, Maha H. Hussain, MD, will join the Robert H. Lurie Comprehensive Cancer Center of Northwestern University as the Associate Director for Clinical Sciences Research. Hussain will also serve as Co-Director of the Lurie Cancer Center's Genitourinary Oncology Program, along with Edward Schaeffer, MD, PhD, Chair of the Department of Urology at Northwestern University Feinberg School of Medicine. more...
Research Highlights
License to Build: New Theory of Cancer Puts Metabolism at Center
Memorial Sloan Kettering Cancer Center
A long-familiar fact about beer making is inspiring some unconventional thinking about cancer. Memorial Sloan Kettering President and CEO Craig Thompson, MD, and postdoctoral fellow Natasha Pavlova argue in a recently published paper that cancer cells take up and use nutrients much like yeast in a vat of sugar, reproducing with wild abandon. Further, they claim that it's this altered metabolism of nutrients - rather than any quirk of a disordered cell cycle - that lies at the heart of cancer. more...
Malignant Brain Tumors Most Common Cause of Cancer Deaths in Adolescents, Young Adults
Case Comprehensive Cancer Center, Case Western Reserve University
A new report finds that malignant brain tumors are the most common cause of cancer-related deaths in adolescents and young adults aged 15-39 and the most common cancer occurring among 15-19 year olds. The study’s senior author is Jill Barnholtz-Sloan, PhD, associate professor, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine and Scientific Principal Investigator for the Central Brain Tumor Registry of the United States. more...
Study Finds Ovarian Cancer Survival Rates Did Not Rise With Increased Paclitaxel
UAB Comprehensive Cancer Center
A study published in the New England Journal of Medicine found that administering the cancer drug paclitaxel weekly versus every three weeks does not prolong progression-free survival among patients with ovarian cancer. For this large, multinational study, investigators from the University of Alabama at Birmingham looked at the combined dose-dense weekly paclitaxel with bevacizumab. Overall, results show that a regimen of weekly paclitaxel did not prolong PFS as compared with a regimen of treatment every three weeks. more...
Space Radiation Key to Controlling Astronaut--and Perhaps Earthbound-- Cancer Risk
University of Colorado Cancer Center
NASA limits an astronaut's radiation exposures to doses that keep their added risk of fatal cancer below 3 percent. Unfortunately, that ceiling restricts the time an astronaut may spend in space, which in turn restricts the ability to perform longer missions. Now a network of research laboratories seeks to understand the mechanisms and effects of space radiation to prevent radiation-induced cancers, both in space and at home. One of these laboratories is that of Michael Weil, PhD, investigator at the University of Colorado Cancer Center, whose recent paper describes attempts to personalize the assessment of radiation-induced cancer risk in astronauts. more...
Study Links Normal Stem Cells to Aggressive Prostate Cancer
University of Texas MD Anderson Cancer Center
A study that revealed new findings about prostate cells may point to future strategies for treating aggressive and therapy-resistant forms of prostate cancer. The study proved that the prostate basal cell layer contains adult stem cells which possess a unique gene expression profile resembling the deadliest form of prostate cancer. The research was led by The University of Texas MD Anderson Cancer Center. more...
PET Imaging Technology Advance Improves Cancer Treatment Response
Jonsson Comprehensive Cancer Center, UCLA
A promising new discovery by UCLA scientists could lead to a new method of identifying cancer patients that express high levels of an enzyme and are more likely to respond to cancer treatments. In a seven-year study, a team of UCLA researchers led by Caius Radu, MD, a UCLA Jonsson Comprehensive Cancer Center member, developed a highly sophisticated PET probe called [18F]CFA that is capable of detecting dCK activity in humans for the first time. more...
Differences in Type of Small Protein May Further Elucidate Lung Cancer Risk in African Americans
Rutgers Cancer Institute of New Jersey
Research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from the National Cancer Institute and other facilities, shows differences in a certain type of small protein vary by race and may contribute differently to the development of lung cancer in African Americans and European Americans. Rutgers Cancer Institute of New Jersey researcher Sharon R. Pine, PhD, is the co-lead author of the study. more...
Is Metastatic Prostate Cancer Tailor-made for Precision Oncology?
Fred Hutchinson Cancer Research Center
Metastatic prostate cancer presents an appealing target for precision oncology, according to new work from scientists at Fred Hutchinson Cancer Research Center and the University of Washington. In a study led by Peter Nelson, MD, the researchers showed that though metastases from different patients varied widely in their genetic characteristics, metastases within a single patient were remarkably similar. more...
Scientists Work to Bring About a New Treatment for Rare Childhood Cancer
VCU Massey Cancer Center
Neuroblastoma is a rare cancer that develops in very early forms of nerve cells in the embryo or fetus, and it accounts for the most pediatric deaths for any tumor outside of the brain. The most lethal form of this tumor is often associated with amplification of the gene MYCN, and now scientists at VCU Massey Cancer Center and the VCU Philips Institute for Oral Health Research may have developed a combination therapy that uses this gene to kill the cancer, instead of making it grow. more...
UCSF Research Suggests New Model for Cancer Metastasis
UCSF Helen Diller Family Comprehensive Cancer Center
Scientists at UC San Francisco have been able to directly observe, for the first time, how invasive cancer cells create a beachhead as they migrate to the lung in a mouse model of metastatic cancer. What they saw was utterly surprising: early "pioneer" cancer cells that lodge in the lung generally die, but first they shed zombie-like particles that move around on their own and get gobbled up by waves of immune cells. Many of these immune cells, as if infected by the cancer particles, then burrow into the lung tissue, opening up space for future cancer cells floating through the blood to settle down safely and form new metastatic colonies. more...
New Treatment Reduces Precancerous Polyps in Hereditary Cancer
Huntsman Cancer Institute
Inheriting a mutation in the APC gene leads to a nearly 100% lifetime risk of colorectal cancer. While colon cancer can be kept at bay by removing the large intestine, these patients also have up to a 15 percent risk of getting cancer in the small intestine, which is the leading cause of cancer death in this patient group. A new study has identified the first prevention treatment for these patients, a two-drug combination that significantly reduces the number and size of precancerous polyps in the small intestine. Jewel Samadder, MD, is the lead researcher on the study. more...
Study Finds Health Disparity in Treatment of Thyroid Goiters
Sidney Kimmel Cancer Center at Thomas Jefferson University
Older patients, minorities, and male patients are more likely to develop substernal thyroid goiters that are difficult to remove surgically, putting them at risk for treatment complications and death, say researchers led by Alliric I. Willis, MD. A study which looked at almost 111,000 patients from the National Inpatient Sample years 2000-2010 who had surgery to remove their goiters documents what investigators say appears to be disparity in demographics and outcomes. more...
New Image Analytics May Offer Quick Guidance for Breast Cancer Treatment
Case Comprehensive Cancer Center, Case Western Reserve University
For women with the most common type of breast cancer, a new way to analyze magnetic resonance images (MRI) data appears to reliably distinguish between patients who would need only hormonal treatment and those who also need chemotherapy, researchers from Case Western Reserve University report. The analysis may provide women diagnosed with estrogen positive-receptor (ER-positive) breast cancer answers far faster than current tests and, due to its expected low cost, open the door to this kind of testing worldwide. more...
Report: AYA Blood Cancer Patients Face Psychological Trauma
The University of Chicago Medicine Comprehensive Cancer Center
Researchers at the University of Chicago Medicine Comprehensive Cancer Center have found that many adolescents and young adults (AYAs) diagnosed with blood cancers, or hematologic malignancies, face significant psychological trauma during and after treatment. And, this type of distress is often overlooked by health care providers. more...
IOM Report Underscores Diversity of Ovarian Cancer Subtypes
Roswell Park Cancer Institute
Ovarian cancer is actually a constellation of different cancers that may originate in other organs and should not be treated as a single disease, concludes a new congressionally mandated report on the state of ovarian cancer incidence, treatment and research. The report, published by the Institute of Medicine (IOM) of the National Academies of Sciences, Engineering, and Medicine, also highlights persistent serious disparities in delivery of care across different groups of women in the U.S., and suggests promising areas for further research. Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director and Chair of Gynecologic Oncology at Roswell Park Cancer Institute, was a co-author of the study. more...
Racial, Socioeconomic Disparities in Early-Stage Breast Cancer Test Highlighted
University of Colorado Cancer Center
A University of Colorado Cancer Center study used 143,032 patient records to show that African American patients are significantly less likely to receive a common test that predicts the seriousness of early-stage, estrogen-receptor-positive breast cancer. It also revealed that African American patients who were tested had significantly higher scores, indicating an overall higher likelihood of having aggressive tumor biology that would benefit from chemotherapy. more...
Dietary Glycemic Index Linked to Lung Cancer Risk in Select Populations
University of Texas MD Anderson Cancer Center
Consuming a diet with a high glycemic index, a classification of how rapidly carbohydrates elevate blood sugar levels, was independently associated with an increased risk of developing lung cancer in non-Hispanic whites, according to a new epidemiologic study from The University of Texas MD Anderson Cancer Center. This research represents the largest study to investigate potential links between glycemic index and lung cancer. more...
Improved ’Liquid Biopsy’ Technique Enhances Detection of Tumor DNA in Blood
Stanford Cancer Institute
Researchers at the Stanford University School of Medicine have devised a way to significantly increase the sensitivity of a technique to identify and sequence DNA from cancer cells circulating in a person's blood. The hope is that such "liquid biopsies" of easily obtained blood samples could one day replace the need to surgically obtain tumor tissue for study. more...
Study Identifies Possible Marker for Lung Cancer Chemotherapy
The Ohio State University Comprehensive Cancer Center
James Cancer Hospital & Solove Research Institute

The activity level of a particular gene in lung-tumors might identify lung cancer patients who will likely be helped by a particular chemotherapy regimen given to prevent recurrence after surgery. The finding comes from a study led by researchers at The Ohio State University Comprehensive Cancer Center- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The study looked at the expression of a gene called SMARCA4/BRG1 in tumor cells from patients with earlier-stage non-small-cell lung cancer. It found that low SMARCA4 expression signals a poor prognosis, but also a significant sensitivity to the chemotherapy drug cisplatin. more...
Researchers Identify New Strategy for Discovering Colorectal Cancer Drugs
UF Health Cancer Center
University of Florida pharmacy researchers have identified novel drug targets and a new screening method for drugs affecting the signaling pathways in colorectal cancer. Hendrik Luesch, PhD, and Long H. Dang, MD, PhD, have devised a strategy whereby multiple cancer pathways may be targeted simultaneously for drug discovery. Many of the proteins currently under investigation as possible targets for cancer therapy are found in these pathways. more...
Negative Cancer Trials: Short-Term Whimper, Long-Term Bang
Fred Hutchinson Cancer Research Center
Cancer clinical trials with negative results don't make an immediate splash in the scientific literature, but they do have a long-term impact on cancer research, according to a new study by SWOG, the federally funded international clinical trials network. more...
Stress-Reduction for Pediatric Stem Cell Transplant Caregivers Shows Benefit
Rutgers Cancer Institute of New Jersey
Research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from other facilities across the country, shows a social-cognitive intervention designed for parents of children undergoing a stem cell transplant had beneficial effects in reducing caregiver distress during the hospitalization period as compared with current best-practice psychosocial care. Rutgers Cancer Institute Associate Director for Cancer Prevention, Control and Population Science Sharon Manne, PhD, is the lead author of the work. more...
Study Shows New Insights Into How Cells are Wired to Survive Radiation Therapy
Jonsson Comprehensive Cancer Center, UCLA
A UCLA-led study has for the first time shown that microRNAs, specifically the microRNA known as miR-34, can sit silently in an inactive state in a cell waiting for a signal to turn it on. The discovery counters the long-held notion that a microRNA when made is always already activated and ready to work, and shows for the first time that microRNAs can be controlled in a way similar to proteins, waiting for stress signals to turn them on. Joanne Weidhaas, MD, PhD, MSM, is the study's lead author. more...
For Prostate Cancer, More Radiation May Not Improve Survival
Sidney Kimmel Cancer Center at Thomas Jefferson University
New technology has enabled doctors to administer higher doses of radiation to prostate cancer patients with fewer side effects. However, a new study shows that escalating the dose may not actually help a patient in the long term, at least not patients with localized prostate cancer. more...
Computer Models Simulating Stem Cell Transplant Recovery Developed
VCU Massey Cancer Center
Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants. In two recent studies, they reinforce the potential of using DNA sequencing and computer modeling to predict which stem cell transplant recipients might suffer complications such as graft-versus-host-disease, a condition where the donor's immune system attacks the recipient's body. The studies build upon prior research by scientists at VCU Massey Cancer Center, the VCU Center for the Study of Biological Complexity and VCU's Department of Psychiatry and Statistical Genomics that found evidence that the immune system may be modeled as a dynamical system. more...
Other News
Partnership Aims to Reduce Tobacco-Related Cancer
UK Markey Cancer Center
To address tobacco-related health disparities in Appalachia, the Centers for Disease Control and Prevention (CDC) has designated a coalition based at the University of Kentucky College of Public Health as the newest member of the SelfMade Health Network (SMHN). The CDC's SelfMade Health Network is a national network of dedicated professionals, organizations and communities seeking to eliminate tobacco-related health disparities in underserved or high-risk populations. The UK College of Public Health, in coordination with the Kentucky Cancer Program and the Kentucky Cancer Consortium, will serve as a Regional Resource Lead Organization within the SMHN. more...
Huntsman Hosts Vice President Biden
Huntsman Cancer Institute
Huntsman Cancer Institute (HCI) hosted Vice President Joe Biden in late February as part of the White House administration's "moonshot" initiative to double the rate of progress toward curing cancer. During his visit, the vice president toured the facility, was given an inside look at the Utah Population Database and participated in a roundtable discussion comprised of Huntsman Cancer Foundation board chairman Jon Huntsman Jr., CEO and director of HCI Dr. Mary Beckerle and Senator Orrin Hatch. Local cancer survivors and physicians, researchers and experts in the field also participated in the roundtable. more...
VP Biden Discusses Cancer Moonshot with UCSF Experts
UCSF Helen Diller Family Comprehensive Cancer Center
Vice President Joe Biden and his wife Jill Biden, PhD, visited UC San Francisco on in late February to discuss the administration's national "Moonshot" initiative to improve cancer outcomes in the next decade. The Bidens' visit was the latest stop on a national listening tour to meet with scientists to learn how they can help improve the process of cancer research, as well as meet with cancer patients and survivors to help improve care. The UCSF visit began with a tour of cancer research labs at the Mission Bay campus, followed by a spirited and at times emotional roundtable discussion. more...
Lehigh Valley is New Member of MSK Alliance
Memorial Sloan Kettering Cancer Center
The Lehigh Valley Health Network Cancer Institute is now a formal member of the Memorial Sloan Kettering (MSK) Cancer Alliance, a transformative initiative to improve the quality of care and outcomes for people with cancer in community healthcare settings. Representatives of both organizations made the announcement at Lehigh Valley Hospital–Cedar Crest following an intensive six-month collaborative review process. more...
Job Opportunities
Flow Cytometry Shared Service Director  
University of Maryland
Marlene & Stewart Greenebaum Cancer Center

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Administrative Director  
Norris Cotton Cancer Center-Clinical Research Office
Dartmouth College

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Clinical Research Administrator  
UC Irvine, Chao Family Comprehensive Cancer Center

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Executive Administrative Director  
UC Cancer Institute

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Executive Administrative Director (EAD), Cancer Clinical Trials Office  
Stanford Cancer Institute

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Associate Center Director for Population Sciences and Policy  
GW Cancer Center
Milken Institute School of Public Health
The George Washington University

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Associate Director for Administration  
The University of Hawaii Cancer Center

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Meeting Announcements

CCAF 2016 Spring Meeting

Sunday, April 3 through Tuesday, April 5
The meeting will be held in downtown Fort Worth at the Renaissance Worthington Hotel. A preliminary agenda and meeting registration can be found here: utsouthwestern.edu

2016 NACCDO/PAMN Annual Conference

Please join us for the 2016 NACCDO/PAMN Annual Conference from Tuesday, April 5, through Friday, April 8, hosted by City of Hope at the Langham Huntington Hotel in Pasadena, CA. You may register for the conference here.

2016 Capitol Hill Day

AACI will co-host its annual Capitol Hill Day with the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO).
May 11-12, 2016
Washington, DC
Register to attend today!

8th Annual AACI Clinical Research Initiative Meeting

Save the Date!
July 20-21, 2016
Loews Chicago O'Hare Hotel
Register now! Registration rates will increase on April 30. Please also note that the deadline for submitting abstracts for consideration for presentation at the meeting is Monday, May 9, at 5:00 PM PST.

2016 AACI/CCAF Annual Meeting

Save the Date!
October 23-25, 2016
Westin Chicago River North
Chicago, IL